Supplementary Video 1 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Chuanjie Zhang; Hongchao He; Yi Gao; Jiawei Ding; Hai Huang; Yixun Liu; Hanqing Liu; Jun Xiao; Dan-feng Xu; Zunguo Du; Zhenbo Zhang; Lechi Ye

doi:10.1158/0008-5472.30255649

October 1, 2025Open Access

Supplementary Video 1 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

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Key Points

BBOX1 acts as a metabolic checkpoint, helping cancer cells evade detection by NK cells.
Live imaging revealed significant differences in behavior of BBOX1pos and BBOX1neg cells during immune interactions.
Coculture of NK cells with cancer cells utilized microscopy to visualize immune evasion mechanisms.
Understanding this evasion could lead to improved strategies for targeting metastatic cancer cells.

Implication

Live imaging demonstrates the role of BBOX1 in evading immunosurveillance by NK cells in cancer, suggesting potential therapeutic targets.

Abstract

Live imaging of coculture of mouse splenic NK cells (green border line) and Renca-derived BBOX1pos or BBOX1neg cells (white border line) using video microscopy.

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21976 https://doi.org/10.1158/0008-5472.30255649

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Supplementary Video 1 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Video 1 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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