Supplementary Figure S7 from Genomic and Epigenomic ctDNA Profiling in Liquid Biopsies from Heavily Pretreated Patients with DNA Damage Response–Deficient Tumors

Key Points

Analysis reveals notable ATM reversions in ctDNA from two heavily pretreated patients, indicating specific genetic alterations.
Genomic profiling of ctDNA identified ATM reversions, showcasing the potential of liquid biopsies in precision medicine.
Assessment of liquid biopsies through genomic and epigenomic profiling highlights the utility in tracking tumor evolution.
Findings suggest that ctDNA analysis could guide treatment decisions for patients with DNA damage response-deficient tumors.

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Analysis explores ctDNA in liquid biopsies from patients with DNA damage response deficiencies, suggesting significant insights into ATM reversions.

IGV screenshots for two patients with ATM reversions.

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Silverman et al. (2025) studied this question.

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