Supplementary Figure S5 from Genomic and Epigenomic ctDNA Profiling in Liquid Biopsies from Heavily Pretreated Patients with DNA Damage Response–Deficient Tumors

This is a Quantitative Study study (also classified as: Cohort Study).

Key Points

Reversion detection linked to clinical and genomic traits in patients with DNA damage response–deficient tumors.
Patients heavily pretreated show significant findings in tumor genomic profiles and ctDNA analysis.
Observational analysis of liquid biopsies reveals essential data for understanding tumor reversion mechanisms.
Implications underscore potential for tailored approaches in managing patients with resistant tumors.

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Analysis identifies genomic and clinical traits linked to reversion in patients with tumors, suggesting new diagnostic approaches.

Reversion detection by clinical and genomic characteristics.

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Silverman et al. (2025) studied this question.

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