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October 1, 2025

Supplementary Figure 7 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Chuanjie Zhang Hongchao He Yi Gao Jiawei Ding Hai Huang Yixun Liu Hanqing Liu Jun Xiao Dan-feng Xu Zunguo Du Zhenbo Zhang Lechi Ye

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Key Points

The metabolic checkpoint BBOX1 mediates cancer cell evasion from NK cell immunosurveillance, affecting tumor progression.
RhoA activity suppression by carnitine facilitates RhoA's binding with RhoGDI2, enhancing evasion strategies in metastatic cancer cells.
Observational analysis revealed the role of carnitine in metabolic regulation and immunoevasion in cancer models.
This investigation implies new therapeutic targets may focus on RhoA inhibition to enhance NK cell responses against tumors.

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Implication

Supplementary figure identifies how cancer cells evade immunosurveillance by NK cells, suggesting RhoA inhibition by carnitine plays a crucial role.

Abstract

Carnitine suppresses RhoA activity via facilitating its binding with RhoGDI2.

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a219b5 https://doi.org/10.1158/0008-5472.30255667

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 6 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
2Supplementary Figure 5 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
3Supplementary Figure 3 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
4Supplementary Figure 8 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
5Supplementary Figure 4 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025