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October 1, 2025

Supplementary Figure 6 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Chuanjie Zhang Hongchao He Yi Gao Jiawei Ding Hai Huang Yixun Liu Hanqing Liu Jun Xiao Dan-feng Xu Zunguo Du Zhenbo Zhang Lechi Ye

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Key Points

BBOX1 serves as a metabolic checkpoint, enabling cancer cells to evade NK cell immunosurveillance.
Experiments show that carnitine inhibits RhoA activity and prevents F-actin-driven immune synapse formation.
This research highlights potential strategies to enhance immunotherapy effectiveness against metastatic cancers.
Finding effective ways to disrupt BBOX1 function may improve treatment outcomes for patients with metastatic cancer.

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Implication

Research reveals BBOX1 as a metabolic checkpoint influencing metastatic cancer cell evasion from NK cells, suggesting new therapeutic targets.

Abstract

Carnitine inhibits RhoA activity to prevent F-actin-driven IS formation.

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a219b7 https://doi.org/10.1158/0008-5472.30255670

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 7 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
2Supplementary Figure 5 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
3Supplementary Figure 3 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
4Supplementary Figure 8 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
5Supplementary Figure 4 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025