Supplementary Figure 5 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Chuanjie Zhang; Hongchao He; Yi Gao; Jiawei Ding; Hai Huang; Yixun Liu; Hanqing Liu; Jun Xiao; Dan-feng Xu; Zunguo Du; Zhenbo Zhang; Lechi Ye

doi:10.1158/0008-5472.30255673

October 1, 2025Open Access

Supplementary Figure 5 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

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Key Points

The metabolic checkpoint bbox1 mediates evasion of metastatic cancer cells from nk cells and immune surveillance.
Findings indicate that carnitine suppresses nk cell activity, independent of receptor alterations or immune composition changes.
Research utilized supplementary figure analysis and focused on immune suppression mechanisms in cancer cells evading nk cells.
These insights highlight potential targets for improving immunotherapy strategies in metastatic cancer treatment.

Implication

Analysis reveals bbox1 as a pivotal metabolic checkpoint guiding metastatic cancer evasion from NK cells, suggesting immune suppression by carnitine.

Abstract

The immune suppression effect of carnitine on NK cells is independent of activating or inhibitory NK receptors or intrinsic alterations in immune composition.

Discussion

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a7d https://doi.org/10.1158/0008-5472.30255673

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Supplementary Figure 5 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 5 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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