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October 1, 2025

Supplementary Figure 4 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Chuanjie Zhang Hongchao He Yi Gao Jiawei Ding Hai Huang Yixun Liu Hanqing Liu Jun Xiao Dan-feng Xu Zunguo Du Zhenbo Zhang Lechi Ye

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Key Points

BBOX1 acts as a metabolic checkpoint for metastatic cancer cells and influences their interaction with NK cells.
NK cell depletion results in higher lung metastasis growth, particularly in tumor cells lacking BBOX1.
The study indicates that BBOX1 negation could enhance metastatic potential by evading immunological detection.
Targeting this metabolic checkpoint may provide new therapeutic avenues for combating metastatic cancers.

Implication

NK cell depletion increases lung metastasis growth in bbox1 negative tumor cells, suggesting a metabolic checkpoint's role.

Abstract

NK cell depletion selectively increases lung metastasis growth by BBOX1neg tumor cells.

Discussion

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a219d4 https://doi.org/10.1158/0008-5472.30255676

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 2 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
2Supplementary Figure 3 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
3Supplementary Figure 8 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
4Supplementary Figure 5 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
5Supplementary Figure 6 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025