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October 1, 2025

Supplementary Figure 2 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Chuanjie Zhang Hongchao He Yi Gao Jiawei Ding Hai Huang Yixun Liu Hanqing Liu Jun Xiao Dan-feng Xu Zunguo Du Zhenbo Zhang Lechi Ye

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Key Points

BBOX1 mediates cancer cell evasion from immunosurveillance by NK cells, impacting metastasis.
Both BBOX1 positive and negative tumor cells showed no significant differences in tumorigenicity and proliferation.
Evaluation involved assessing migration abilities in BBOX1 expressing and non-expressing tumor cells.
Understanding BBOX1's role may help develop strategies against cancer cell evasion, requiring further exploration.

Implication

Supplementary results reveal BBOX1 affects metastatic cancer cell evasion from NK cells, suggesting a role in immunosurveillance.

Abstract

BBOX1pos and BBOX1neg tumor cells do not differ in tumorigenicity, in vitro proliferation and migration ability.

Discussion

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a219e2 https://doi.org/10.1158/0008-5472.30255682

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 4 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
2Supplementary Figure 3 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
3Supplementary Figure 8 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
4Supplementary Figure 5 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
5Supplementary Video 1 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025