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October 1, 2025

Supplementary Figure 3 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells

Chuanjie Zhang Hongchao He Yi Gao Jiawei Ding Hai Huang Yixun Liu Hanqing Liu Jun Xiao Dan-feng Xu Zunguo Du Zhenbo Zhang Lechi Ye

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Key Points

BBOX1 expression in tumor cells is linked to their ability to evade immune detection.
Carnitine dependency of bbox1-positive cancer cells is crucial for their metastatic potential.
NK cells, critical for immune surveillance, are impeded by bbox1-expressing metastatic cells.
The study underscores the metabolic role of bbox1 in promoting cancer cell survival during metastasis.

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Implication

Analysis shows that bbox1 positively affects metastatic cancer cells, suggesting a role in immune evasion by nk cells.

Abstract

BBOX1pos tumor cells depend on carnitine for metastatic spreading.

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a219d5 https://doi.org/10.1158/0008-5472.30255679

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 4 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
2Supplementary Figure 2 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
3Supplementary Figure 5 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
4Supplementary Figure 8 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025
5Supplementary Figure 6 from BBOX1 Is a Metabolic Checkpoint That Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by NK Cells2025