(A) Histopathological analysis images of certain organs in the 3 CAR-treated groups following full necropsy on day 30. Representative regions displaying lesion or absence of lesion at 20magnification are stained with H&E. Scale bar 100 microns. (B) Histologic examination of various organs and tissues on day 30 after CAR T cell treatment. (C) Serum chemistry values of mice on day 30 after CAR T cell treatment. Red represents higher than reference range and blue represents lower than reference range.
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Cai et al. (2024) studied this question.
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