Abnormal spontaneous brain activity and functional connectivity in children with new-onset type 1 diabetes mellitus

It is unclear whether brain activity and functional connectivity (FC) will change in type 1 diabetes mellitus (T1DM) children. We investigated brain activity and FC changes in new-onset T1DM children based on fractional amplitude of low-frequency fluctuation (fALFF) and seed-based FC analysis. We found that children with new-onset T1DM showed changed fALFF values and FCs in several brain regions. Changed fALFF values were correlated with intelligence quotient (IQ) and blood glucose level. These results suggest that altered brain spontaneous activity and FC in initial-stage T1DM patients may be the potential mechanisms of subsequent visual impairment and cognitive dysfunction.