Key result
Type 1 diabetes in youth is linked to higher frontal-parietal activation despite similar task performance.
Why the study?
Children with type 1 diabetes have subtle cognitive deficits relative to neurotypical controls, but the neural correlates of these differences remain poorly understood.
Does functional near-infrared spectroscopy detect differences in brain functional activations during a response inhibition task in youth with type 1 diabetes compared to healthy controls?
Population
19 individuals with type 1 diabetes and 18 healthy controls aged 8-16 years
Comparison
Individuals with type 1 diabetes vs healthy controls
Design
Pilot study
Authors
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Supports fNIRS for detecting altered executive networks in pediatric type 1 diabetes; leaves open validation against cognitive outcomes in longitudinal studies.
Cross-Sectional (n=37)
Does functional near-infrared spectroscopy detect differences in brain functional activations during a response inhibition task in youth with type 1 diabetes compared to healthy controls?
fNIRS detects increased frontal-parietal network activation in youth with type 1 diabetes during executive function tasks, suggesting its utility as a pediatric neuroimaging tool.
Mazaika et al. (2020) conducted a cross-sectional in Type 1 diabetes (n=37). Type 1 diabetes vs. Healthy controls was evaluated on Brain functional activations during a Go/No-Go response inhibition task. Youth with type 1 diabetes exhibited higher fNIRS activations in a frontal-parietal network during a Go/No-Go task compared to healthy controls, despite similar task performance.
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