Transcriptomic differences between patients with BRCA1mt, BRCA2mt, and HRwt ovarian cancer. RNA-seq was performed on patients with HRwt (n = 375), BRCA1mt (n = 16), and BRCA2mt (n = 15) ovarian cancer. A, Volcano plots showing the distribution of DEGs (P = 0.05; FC > 1.5) in the compared groups as indicated. B, Venn diagram of DEGs in each of the groups compared showing 163 genes unique to BRCA2mt tumors. C, Venn diagram of differentially regulated pathways in each of the groups compared showing six pathways unique to BRCA2mt tumors compared with BRCA1mt and HRwt; these six pathways are shown in D.
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Chehade et al. (2024) studied this question.
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