The noncanonical Wnt pathway is activated upon loss of BRCA1. A, Model of the noncanonical Wnt signaling pathway. B, ID8 mouse ovarian cancer cells were treated with 100 ng/mL Wnt3A followed by immunofluorescence for F-actin (green). DAPI staining is shown in blue. Red arrows point to F-actin filaments. Images show both green and DAPI channels. C, Biological processes related to filament and microtubule polymerization are differentially regulated in BRCA1mt vs. BRCA2mt and HRwt ovarian tumors. DAPI, 4′,6′-diamidino-2-phenylindole.
No takes yet. Share an insight, caveat, or question.
Chehade et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: