Figure 2 from BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer

Wnt signaling is predicted to be inhibited in BRCA2mt ovarian tumors. A, DEGs comparing BRCA2mt vs. BRCA1mt and (B) BRCA2mt vs. HRwt reported as logFC; red bars represent upregulated, and blue bars represent downregulated; note that several Wnt inhibitors are upregulated in BRCA2mt tumors (red asterisk). C, Perturbation analysis of the Wnt signaling pathway comparing BRCA2mt and BRCA1mt tumors; red genes are predicted to be upregulated, and blue genes are predicted to be downregulated; the dashed circle shows β-catenin is predicted to be downregulated. Red arrows indicate upregulation of several Wnt signaling inhibitors at the level of the receptor.