Figure 4 from BRCA Status Dictates Wnt Responsiveness in Epithelial Ovarian Cancer

β-Catenin is stabilized upon loss of BRCA2. A, ID8 mouse ovarian cancer cells were treated with 10 µg/mL cycloheximide at designated time points, and levels of β-catenin were determined by Western blot analysis. B, Quantification of A. C, ID8 mouse ovarian cancer cells were treated with 50 µmol/L MG132, and levels of phosphorylated and total β-catenin were determined by Western blot analysis. D, Figures depicting components of the β-catenin destruction complex. E, Basal levels of phosphorylated and total GSK3β were determined by Western blot analysis. NT, no treatment. (Created with Biorender.com.)