Figure 7 from Membrane-bound Heat Shock Protein mHsp70 Is Required for Migration and Invasion of Brain Tumors

Therapeutic efficacy of the HSP70 inhibitors PES and JG98 in orthotopic brain tumor models. The survival curves of the glioma-bearing animals were analyzed employing the Kaplan–Meier method. A, Schematic representation of the preclinical study protocol. B, Kaplan–Meier curves of animals treated with PBS, PES, or JG98. C, Volumetric studies of the C6 rat glioma and U251 human glioblastoma. Tumor volume (mm³) was determined by employing T₁-weighted and T₂-weighted MRI scans in tumor-bearing animals (n = 6 per group). Data are presented as mean ± SD. D, Kaplan–Meier curves of animals treated with PBS, PES, or JG98 in combination with a single-dose (10 Gy) irradiation.