Figure 4 from Exosomal Thomsen–Friedenreich Glycoantigen: A New Liquid Biopsy Biomarker for Lung and Breast Cancer Diagnoses

Blinded evaluation of exosomal TF-Ag-α in lung cancer diagnosis using a test set of patients with lung cancer and controls. A, Exosomal TF-Ag-α expression was significantly higher in serum samples from patients with lung cancer at all stages (total n = 20; stage I/II: n = 10; stage III/IV: n = 10) than normal controls (n = 6; ****, P < 0.0001). B, ROC curve of comparison between patients with lung cancer (n = 20) and normal controls (n = 6). The AUC was 1.00. C, The sensitivity (SEN) and specificity (SPE) of exosomal TF-Ag-α in distinguishing patients with lung cancer from normal controls using a cutoff value of 0.441 obtained from the training set.