Figure 7 from Exosomal Thomsen–Friedenreich Glycoantigen: A New Liquid Biopsy Biomarker for Lung and Breast Cancer Diagnoses

Blinded evaluation of exosomal TF-Ag-α in breast cancer diagnosis using a test set of patients with breast cancer and controls. A, Exosomal TF-Ag-α expression was significantly higher in serum samples from patients with breast cancer at all stages (total n = 25; stages 0–IV, 5 per stage) than normal controls (n = 5 including 2 patients with benign breast conditions; ****, P < 0.0001). B, ROC curve of comparison between patients with breast cancer (n = 25) and normal controls (n = 5). The AUC was 1.00. C, The sensitivity (SEN) and specificity (SPE) of exosomal TF-Ag-α in distinguishing patients with breast cancer from normal controls using a cutoff value of 0.484 obtained from the training set.