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August 2, 2024GliaOpen Access

Early nuclear phenotypes and reactive transformation in human iPSC‐derived astrocytes from ALS patients with SOD1 mutations

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Authors

VSVincent SoubannierMCMathilde ChaineauLGLale Gursu

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Soubannier et al. (2024) studied this question.

synapsesocial.com/papers/68e5d9edb6db64358756fd2fhttps://doi.org/10.1002/glia.24598
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Astrocytes, SOD1 and Amyotrophic Lateral Sclerosis: Mechanisms and Implications in Neurodegeneration2024
  2. 2Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS2013 · 57 citations
  3. 3Comparative Temporal Transcriptomic Analysis of SOD1 Mutations in iPSC-Motor Neurons2025
  4. 4Adult aberrant astrocytes submitted to late passage cultivation lost differentiation markers and decreased their pro-inflammatory profile2024
  5. 5Nuclear Localization of Human SOD1 in Motor Neurons in Mouse Model and Patient Amyotrophic Lateral Sclerosis: Possible Links to Cholinergic Phenotype, NADPH Oxidase, Oxidative Stress, and DNA Damage2024 · 6 citations