Perindopril and losartan affect ACE-2 and IL-6 expression in obese rat model

Andrianto Andrianto; Hanestya Oky Hermawan; Primasitha Maharany Harsoyo; Bagas Si Zaini; Akbar Reza Muhammad

doi:10.52225/narra.v4i2.681

July 15, 2024Narra JOpen Access

Perindopril and losartan affect ACE-2 and IL-6 expression in obese rat model

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Key Points

Losartan administration significantly increased visceral adipocyte ACE2 expression compared to perindopril treatment in obese rats over four weeks of daily therapy.
In vivo true experimental design evaluated 24 adult male albino rats across groups, measuring visceral fat tissue via enzyme-linked immunosorbent assay.
Highlights potential renin-angiotensin modulation of adipocytes during cytokine storm, though findings remain restricted to this rat model requiring clinical validation.

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Implication

In vivo experimental study reveals losartan elevates visceral adipocyte ACE2 expression in obese rats, highlighting potential modulation of inflammatory signaling pathways.

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Andrianto et al. (2024) studied this question.

synapsesocial.com/papers/68e60550b6db6435875987dc https://doi.org/10.52225/narra.v4i2.681

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Perindopril and losartan affect ACE-2 and IL-6 expression in obese rat model

Key Points

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Implication

Discussion

Cite This Study

Perindopril and losartan affect ACE-2 and IL-6 expression in obese rat model

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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