Supplementary Figure 9 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation

This is the authors' abstract. We don't add key points for this paper.

Supplementary Figure 9: Microbial Composition Variability by Sex in BBN-Exposed Mice BBN Gender Female: A: Alpha diversity indices (ACE, Chao1, Shannon) across different time points (0, 6, 12, 16-22 weeks), showing variations in microbial diversity in female mice. B: Stacked bar chart illustrating the relative abundance of bacterial genera at each time point. C: Dot plot depicting the percentage of specific bacterial families at different time points, providing a quantitative view of how predominant families fluctuate with BBN exposure. D: Principal Coordinates Analysis (PCoA) plot based on weighted UniFrac distances, showing the clustering of microbial communities across time, with color-coded points representing different time points to visualize the trajectory of community changes. E: Bar chart with Linear Discriminant Analysis (LDA) scores of bacterial taxa that are significantly different across the studied time points. BBN Gender Male: F: Alpha diversity indices (ACE, Chao1, Shannon) displayed across the same time points as the female group, illustrating the microbial diversity dynamics in male mice. G: Stacked bar chart showing the relative abundance of bacterial genera in male mice, and the specific microbial shifts unique to male physiology under BBN influence. H: Dot plot of the percentage representation of bacterial families over time, helps in identifying sex-specific microbial behavior in response to carcinogenic treatment. I: PCoA plot for the male group, illustrating shifts in microbial community structure with different clusters for each time point. J: LDA score bar chart for male mice displaying significant microbial taxa changes over time providing insight on impact of BBN exposure on the male gut microbiome.