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October 8, 2025Open Access

Evaluating anaesthetics for improving scientific research and welfare using larval zebrafish

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Authors

SDSylvia DimitriadouMMMhairi MillerAPAli Pilehvar

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Overview

Assessment of anaesthetic efficacy in larval zebrafish indicates specific compounds enhance research outcomes, highlighting animal welfare.

Key Points

  • MS222 and quinaldine sulfate are identified as the most effective anaesthetics for deep sedation in larval zebrafish.
  • Only quinaldine sulfate was found to be aversive, likely affecting animal welfare during research protocols.
  • Studies emphasizing cardiovascular performance may benefit from using etomidate to ensure accurate assessment.
  • The findings assist researchers in selecting appropriate anaesthetics for larval zebrafish, promoting improved research quality.

Cite This Study

Dimitriadou et al. (2025) studied this question.

synapsesocial.com/papers/68e6679587ecc93a24d17619https://doi.org/10.1101/2025.10.06.680636
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluating Anesthetics for Improving Scientific Research and Welfare Using Larval Zebrafish2026
  2. 2Evaluation of the Effectiveness of Eugenol and MS-222 as Anesthetics in Zebrafish in Repeated Exposures and Post-Anesthesia Behaviour2024 · 4 citations
  3. 3Menthol as a sustainable alternative anaesthetic for adult zebrafish (Danio rerio)2025
  4. 4Evaluation of thymol application for anaesthesia of adult zebrafish2025
  5. 5Anaesthetic profile of thymol and menthol in zebrafish larvae model2024 · 4 citations