In Vitro Anti-Ulcer Activity Of Vempam Poo (Flower Of Azadirachta Indica) Ooral Kudineer – Siddha Herbal Drug

Introduction and Aim: Peptic ulcer disease (PUD) is prevalent among population. It is a global problem with a lifetime risk of development ranging from 5% to 10%.In present day, global population evolution towards herbal remedies for complete healing of disease. Many herbs have better remedies for the management of peptic ulcer. Siddha system is one of the traditional medicine in India, which is helpful in treating the disease by using herbs, metals,minerals and animal products. Among them, flower of Azadirachta indica (Vempam poo) ooral kudineer is indicated for ulcer (Gunmam) in Siddha literature. The aim of the study is to evaluate the Anti ulcer activity of Vempam poo ooral kudineer (VOK). Material and Methods: Anti-ulcer activity was assessed using in vitro method of Acid neutralizing capacity and H+/K+ - ATPase inhibition activity. Results: The result revealed that the extract of VOK at concentration100mg, 500mg,1000mg showed a significant reduction in acid neutralizing capacity (ANC), i.e., 124,12.3,10.75 respectively, as compared to standard Al(OH)3+Mg(OH)2 (500 mg) which is 15.VOK significantly inhibits the enzyme H+/K+ - ATPase, which is responsible for the secretion of acid and effect was comparable to omeprazole. Conclusion: The study concluded that the Vempam poo ooral kudineer(VOK) has anti ulcer activity by acid-neutralizing capacity (ANC) and inactivation of H+ /K+ ATPase.