April 1, 2024Biophysical ReviewsOpen Access

An overview on glycation: molecular mechanisms, impact on proteins, pathogenesis, and inhibition

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Authors

AUAna Belén UcedaServei de Salut de les Illes Balears LMLaura MariñoCentre National de la Recherche Scientifique RCRodrigo CasasnovasHealth Research Institute of the Balearic Islands

Discussion

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Implication

Review demonstrates how advanced glycation end products impair macromolecular function in hyperglycemic conditions, highlighting avenues for therapeutic inhibition.

Key Points

Advanced glycation end products accumulate on long-lived proteins under hyperglycemic conditions, driving structural damage and triggering widespread pathophysiological complications.
Review outlines non-enzymatic glycation mechanisms across biomolecules, highlighting computational chemistry insights into protein aggregation and cellular dysfunction.
Highlights both endogenous protective defenses and exogenous glycation inhibitors, establishing molecular targets to counteract diabetic, neurological, and renal pathologies.

Cite This Study

Uceda et al. (2024) studied this question.

synapsesocial.com/papers/68e70d8cb6db643587686f42 https://doi.org/10.1007/s12551-024-01188-4

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Implication

Review demonstrates how advanced glycation end products impair macromolecular function in hyperglycemic conditions, highlighting avenues for therapeutic inhibition.

An overview on glycation: molecular mechanisms, impact on proteins, pathogenesis, and inhibition

Discussion

Member takes

Implication

Key Points

Cite This Study

An overview on glycation: molecular mechanisms, impact on proteins, pathogenesis, and inhibition

Discussion

Member takes

Implication

Key Points

Cite This Study

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