What question did this study set out to answer?

To examine the mechanisms of protein glycation and its impact on various chronic diseases while highlighting therapeutic options.

April 10, 2026DiseasesOpen Access

Glycation at the Crossroads of Disease Pathogenesis: Mechanistic Insights and Therapeutic Frontiers

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This review explores glycation's role in disease development, suggesting therapeutic targets to mitigate harmful effects.

To examine the mechanisms of protein glycation and its impact on various chronic diseases while highlighting therapeutic options.
Reviewed literature on glycation and advanced glycation end products (AGEs)
Analyzed molecular pathways associated with AGE formation
Summarized advances in analytical detection methods for monitoring AGEs
Discussed the implications of glycation in diseases like diabetes, cardiovascular disease, neurodegeneration, and cancer
Described how AGEs alter protein function and contribute to disease pathogenesis
Identified RAGE as a key mediator of oxidative stress and inflammation
Highlighted the diverse structural forms of AGEs and their biological effects
Outlined emerging therapies aimed at reducing AGE formation and blocking AGE–RAGE signaling

Krishnamoorthi et al. (2026) studied this question.

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