Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 11, 2025Frontiers in Bioscience-EliteOpen Access

Posterior Ciliary Artery Contraction by Bradykinin Receptor Subtypes and Implications for Retinal Blood Flow Dysfunction

View Full Paper
Ask AI
Bookmark
Share

Authors

NSNajam A. SharifCreighton UniversitySOSunny E. OhiaCreighton UniversityMKMadhura Kulkarni-ChitnisCreighton University

Discussion

Loading...

Member takes

Implication

This pharmacological analysis reveals bradykinin potentially narrows retinal blood vessels, suggesting implications for glaucoma.

Key Points

  • Bradykinin agonists cause significant contraction of posterior ciliary arteries, impacting blood flow regulation.
  • High-potency bradykinin receptor agonists exhibit EC50 values spanning from 0.9 nM to 3.0 nM, indicating effective contraction.
  • Pharmacological profiling includes receptor-selective antagonists to elucidate functional receptor dynamics for vascular tone modulation.
  • Findings suggest potential link between kinin receptors and glaucomatous optic neuropathy, highlighting a risk factor for vision loss.

Cite This Study

Sharif et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1d9ba7d64b6fc133074https://doi.org/10.31083/fbe37072
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulated expression of endothelin 1 in glomerular capillary endothelial cells1991 · 107 citations
  2. 2A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle Ca2+ channels1988 · 294 citations
  3. 3Characterization of Endothelin Receptor Subtypes on Airway Smooth Muscle Cells1995 · 13 citations
  4. 4Management of ischemic optic neuropathies2011 · 161 citations
  5. 5Long-term hypoxia uncouples Ca2+and eNOS in bradykinin-mediated pulmonary arterial relaxation2018 · 11 citations