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October 12, 2025Regional Anesthesia The Journal of Neural Blockade in Obstetrics Surgery & Pain Control

Distribution of 3H-Morphine after Lumbar Epidural Administration in Unanesthetized Rabbits

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Authors

BWB. C. Wang DHD. E. Hillman JHJacob M. HillerUniversity of Massachusetts Amherst

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Implication

Study reveals the distribution of 3H-morphine in spinal cord and urine after epidural administration in rabbits, indicating significant impact of time and distance.

Key Points

At 2 hours, 4.2% of the injected radioactivity was recovered from the spinal cord and urine, with amounts varying over time.
Time and distance significantly influenced the distribution of 3H-morphine, as shown by multiple linear regression analysis with p < 0.0001.
Epidural administration of 3H-morphine revealed that most radioactivity concentrated around the injection site and decreased with time and distance.
Recovery of radioactivity in urine was major while small amounts were found in tissues like the bladder, liver, and spinal roots.

Cite This Study

Wang et al. (1992) studied this question.

synapsesocial.com/papers/68eb6f7ceea689731b3006d0 https://doi.org/10.1136/rapm-00115550-199217060-00005

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Implication

Study reveals the distribution of 3H-morphine in spinal cord and urine after epidural administration in rabbits, indicating significant impact of time and distance.

Distribution of 3H-Morphine after Lumbar Epidural Administration in Unanesthetized Rabbits

Discussion

Member takes

Implication

Key Points

Cite This Study

Distribution of 3H-Morphine after Lumbar Epidural Administration in Unanesthetized Rabbits

Discussion

Member takes

Implication

Key Points

Cite This Study

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