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October 13, 2025Thrombosis and Haemostasis

Potent Inhibition of Arterial Thrombosis and Venous Thrombogenesis Subject to Adequate Hemostasis via Disrupting β3/Src Interaction in Platelets

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Authors

SZSiyue ZhengSLShuang LiuYSYan Shen

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Overview

In vitro and in vivo analysis demonstrated that medical compounds C109 and C116 inhibit thrombosis, suggesting improved safety profiles in antithrombotic therapy.

Key Points

  • C109 and C116 effectively inhibit thrombosis at levels comparable to existing antithrombotic agents, without increasing bleeding risk.
  • In vitro and in vivo evaluations showed that these compounds suppressed arterial and venous thrombogenesis efficiently.
  • Targeting the β3/Src interaction offers a promising therapeutic strategy for managing thrombosis while preserving hemostatic function.
  • C109's favorable pharmacokinetic properties highlight its potential for further clinical development and application.

Cite This Study

Zheng et al. (2025) studied this question.

synapsesocial.com/papers/68ece2abd1bb2827d12973f1https://doi.org/10.1055/a-2706-9879
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