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October 15, 2025Open Access

Dickkopf-3 (DKK3) and the progression of diabetic kidney diseasein primary health care

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uDKK3 levels >200 pg/g creatinine are linked to a higher risk of composite kidney endpoints.
In a cohort of 3232 patients with T2DM, uDKK3 improved prediction of 1-year eGFR decline significantly.
High uDKK3 levels correlate with increased risk of cardiovascular events and all-cause mortality.
The study emphasizes the need for primary care to adopt uDKK3 for identifying high-risk patients.

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Cohort study assessed how uDKK3 predicts adverse outcomes in patients with T2DM, suggesting it may guide intensive care.

Keller et al. (2025) studied this question.

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