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This study investigates the relationship between urinary DKK3, albuminuria, and arterial stiffness in diabetic kidney disease.

August 13, 2026Clinical Nephrology

Urinary Dickkopf-3 reflects renal and vascular damage in diabetic kidney disease: A cross-sectional study

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This study investigates the relationship between urinary DKK3, albuminuria, and arterial stiffness in diabetic kidney disease.
Cross-sectional design involving 45 patients with DKD and 30 healthy controls.
Urinary DKK3 levels measured using enzyme-linked immunosorbent assay and normalized to urinary creatinine.
Arterial stiffness assessed by pulse wave velocity using oscillometric device, with correlation and regression analyses applied.
Urinary DKK3/creatinine ratios were significantly higher in DKD patients compared to controls (p < 0.001).
Urinary DKK3 showed strong positive correlations with albuminuria (r = 0.785, p < 0.001) and PWV (r = 0.454, p = 0.023).
In multivariable analysis, urinary DKK3 independently predicted albuminuria (β = 0.546, p = 0.004).

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Implication

Cross-sectional study explores urinary DKK3, albuminuria, and arterial stiffness in diabetic kidney disease, indicating potential for risk stratification.

Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/6a7d76062b0e0cff3f63f0d4 https://doi.org/10.5414/cn112065

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Implication

Cross-sectional study explores urinary DKK3, albuminuria, and arterial stiffness in diabetic kidney disease, indicating potential for risk stratification.

Urinary Dickkopf-3 reflects renal and vascular damage in diabetic kidney disease: A cross-sectional study

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Discussion

Implication

Cite This Study

Urinary Dickkopf-3 reflects renal and vascular damage in diabetic kidney disease: A cross-sectional study

Key Points

Discussion

Implication

Cite This Study

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