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October 15, 2025

Dickkopf-3 (DKK3) and the progression of diabetic kidney diseasein primary health care

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Dickkopf-3 levels above 200 pg/g creatinine indicate a higher risk for significant kidney problems.
In a cohort of 3232 T2DM patients, tracking dickkopf-3 improved predictions for kidney function decline and mortality.
Assessment showed that urinary dickkopf-3 is a useful biomarker alongside traditional measures like albuminuria.
Monitoring dickkopf-3 could guide referrals to specialists and enhance treatment strategies in primary health care.

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Cohort analysis identifies dickkopf-3 predicting kidney function decline in T2DM patients, suggesting clinical utility.

Keller et al. (2025) studied this question.

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