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This is a Quantitative Study study (also classified as: Cohort Study).

October 16, 2025BiomedicinesOpen Access

Clinicopathological Significance of Transcription Factor p73 in Breast Cancers: Protein Expression and Transcriptomic Study

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High cytoplasmic p73 levels are linked to poor breast cancer specific survival and aggressive tumor traits.
In TP53 mutant breast cancers, elevated p73 expression correlates with severe histopathological characteristics.
The study involved assessment of p73 and p53 protein expression in over 1,300 invasive breast cancers.
Cytoplasmic p73 may serve as a potential marker for breast cancer aggressiveness, especially in TP53 mutants.

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Analysis shows p73 protein expression correlates with aggressive breast cancer features, indicating possible prognostic value.

Shoqafi et al. (2025) studied this question.

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