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October 15, 2025

Figure S1 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression

Varadha Balaji Venkadakrishnan Adam Presser Nathaniel C.E. Voss James Neiswender Lisa Brenan Keira Prenza Sosa Kenny Weng Andrés Acosta Francisca Vázquez Himisha Beltran

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Key Points

Castration resistant prostate cancer shows significant changes in epigenetic marks, particularly H3K27me3.
The scatter plot indicates altered log2FPM values in genome-wide bins associated with PROX1.
This analysis highlights the potential mechanisms of neuroendocrine differentiation in prostate cancer.
Findings support the idea that PROX1 derepression could drive tumor progression in resistant cases.

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Implication

Observational analysis reveals elevated H3K27me3 marks in castration resistant tumors, suggesting PROX1's role in prostate cancer progression.

Abstract

Supplementary Figure 1 - Scatter plot with log2FPM values of 10kb genome-wide bins of H3K27me3 in castration resistant

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Cite This Study

Venkadakrishnan et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcae7 https://doi.org/10.1158/0008-5472.30363255

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1Figure S4 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
2Figure S5 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
3Figure S2 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
4Figure S7 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
5Figure S3 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
6Figure S6 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
7Supplementary Data from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
8Cover Art from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025