Figure S2 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression

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This is a Experimental Study study.

Varadha Balaji Venkadakrishnan; Adam G. Presser; Nathaniel C.E. Voss; James Neiswender; Lisa Brenan; Keira Prenza Sosa; Kenny Weng; Andrés Acosta; Francisca Vázquez; Himisha Beltran

doi:10.1158/0008-5472.30363252

October 15, 2025Open Access

Figure S2 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression

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Key Points

Epigenetic derepression of PROX1 enhances neuroendocrine prostate cancer progression, affecting treatment responses.
The analysis shows significant H3K27ac levels in organoids derived from NEPC patients, indicating active regulatory elements.
CUT&RUN method provides insights into epigenetic modifications in the context of prostate cancer biology.
Understanding these mechanisms may suggest new therapeutic targets for managing neuroendocrine prostate cancer.

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Implication

Integrative genomics analysis reveals H3K27ac level associations with PROX1 in neuroendocrine prostate cancer organoids, highlighting cancer progression.

Abstract

Supplementary Figure 2 - Screenshots from Integrative Genomics Viewer of CUT&RUN H3K27ac levels in NEPC patient derived organoids

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Cite This Study

Venkadakrishnan et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dcdd5 https://doi.org/10.1158/0008-5472.30363252

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Figure S2 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression

Key Points

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Implication

Abstract

Discussion

Cite This Study

Figure S2 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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