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October 15, 2025Open Access

Figure S5 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression

Varadha Balaji Venkadakrishnan Adam Presser Nathaniel C.E. Voss James Neiswender Lisa Brenan Keira Prenza Sosa Kenny Weng Andrés Acosta Francisca Vázquez Himisha Beltran

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Key Points

Increased mRNA levels of CHGA and SYP correlate with neuroendocrine prostate cancer progression in models.
Key mRNA markers like DLL3 and INSM1 show significant expression patterns in the WCM154 NEPC model.
The study highlights the role of epigenetic factors in the progression of prostate cancer through PROX1.
Findings suggest that understanding these mRNA levels could inform new therapeutic strategies for neuroendocrine prostate cancer.

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Implication

Supplementary data reveals mRNA levels of key markers in neuroendocrine prostate cancer models, implying deeper biological insights.

Abstract

Supplementary Figure 5 - mRNA levels of CHGA, SYP, DLL3, and INSM1 shown in WCM154 NEPC model137 upon contro

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Cite This Study

Venkadakrishnan et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dcd97 https://doi.org/10.1158/0008-5472.30363240

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1Figure S4 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
2Figure S7 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
3Figure S1 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
4Figure S3 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
5Figure S6 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
6Figure S2 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
7Supplementary Data from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025
8Cover Art from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression2025