Supplementary Data from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression

October 15, 2025Open Access

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Key Points

Epigenetic derepression of PROX1 accelerates neuroendocrine prostate cancer progression, raising concerns over tumor aggressiveness.
Supplementary data includes detailed figure legends and connections to broader cancer biology, elucidating mechanisms behind the progression.
Observational analysis showcases PROX1’s role in cancer pathways, linking genetic and epigenetic factors to disease outcomes.
Findings highlight the need for further exploration of PROX1's role, indicating potential targets for therapeutic intervention.

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Supplementary data reveals how PROX1 influences neuroendocrine prostate cancer, suggesting potential pathways for treatment.

Supplementary data and supplementary figure legends with Biorender link

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Venkadakrishnan et al. (2025) studied this question.

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