Figure S6 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression

Varadha Balaji Venkadakrishnan; Adam G. Presser; Nathaniel C.E. Voss; James Neiswender; Lisa Brenan; Keira Prenza Sosa; Kenny Weng; Andrés Acosta; Francisca Vázquez; Himisha Beltran

doi:10.1158/0008-5472.30363237

October 15, 2025Open Access

Figure S6 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression

View Full Paper

Ask AI

Bookmark

Share

Key Points

The study reveals a significant alteration in the androgen response pathway in organoids expressing PROX1.
Gene set enrichment analysis indicates that PROX1 expression promotes neuroendocrine prostate cancer features.
This analysis compares the effects of dTAGv1 treatment with a vehicle control in organoid models.
These findings suggest that targeting PROX1 could have therapeutic implications in neuroendocrine prostate cancer.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Gene set enrichment analysis reveals enhanced androgen response in organoids with PROX1 restoration, suggesting critical involvement in cancer advancement.

Abstract

Supplementary Figure 6 - Gene Set Enrichment Analysis of androgen response hallmark pathway in WCM154 PROX1 rescue expressing dTAG-HA-PROX1 treated with dTAGv1 for 8 hours vs vehicle treated organoids

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Venkadakrishnan et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dce00 https://doi.org/10.1158/0008-5472.30363237

View Full Paper

Ask AI

Bookmark

Share

Figure S6 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Figure S6 from Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading