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October 15, 2025

Figure S8 from Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production

Zeyu Chen Jingyu Liao Chang Zhu Ruizhi Chang Huifang Liang Zeyang Ding Zhao Huang Xiaoping Chen Jia Liang Bixiang Zhang

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Key Points

Inhibiting SLK enhances tumor growth and glycolysis, showing a crucial link in cancer metabolism.
The intervention led to decreased phosphoenolpyruvate production, with evidence from enzyme activity assays.
The analysis employed exon skipping strategies to target SLK, revealing its role in tumor metabolism.
Findings indicate a potential therapeutic direction for cancer treatment targeting metabolic pathways.

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Implication

Targeting SLK with ASO reduces tumor growth and glycolysis, suggesting therapeutic potential.

Abstract

SLK-targeting ASO inhibits tumor growth and glycolysis

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcb2b https://doi.org/10.1158/0008-5472.30363384

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S2 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
2Figure S3 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
3Figure S7 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
4Figure S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
5Figure S6 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025

Figure S1 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
Table S4 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
Table S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025