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October 15, 2025Open Access

Table S4 from Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production

Zeyu Chen Jingyu Liao Chang Zhu Ruizhi Chang Huifang Liang Zeyang Ding Zhao Huang Xiaoping Chen Jia Liang Bixiang Zhang

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Key Points

Enhanced glycolysis increases tumor progression in specific cell lines by activating enolase 1.
U-13C-glucose metabolic flux analysis showed significant changes in metabolite production.
Analysis included MHCC-97H-SLKv and MHCC-97H-Vector cell lines, indicating variability in glycolytic activity.
The findings suggest that targeting enolase 1 may offer therapeutic strategies in cancer treatment.

Implication

Metabolic flux analysis reveals enhanced glycolysis in tumor cells, suggesting a role in tumor progression.

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dce82 https://doi.org/10.1158/0008-5472.30363372

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S3 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
2Figure S2 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
3Table S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
4Figure S1 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
5Figure S8 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025

Figure S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
Figure S6 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
Figure S3 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025