Figure S1 from Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production

Zeyu Chen; Jingyu Liao; Chang Zhu; Ruizhi Chang; Huifang Liang; Zeyang Ding; Zhao Huang; Xiaoping Chen; Jia Liang; Bixiang Zhang

doi:10.1158/0008-5472.30363414

October 15, 2025

Figure S1 from Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production

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Key Points

Exon skipping enhances glycolysis and tumor progression, activating enolase 1 for increased energy production.
The splicing inhibitor H3B-8800 significantly influences tumor glycolysis and the TCA cycle, suggesting a regulatory role in metabolic pathways.
Through modulation of key metabolic processes, H3B-8800 may serve as a promising agent in cancer therapy targeting glycolysis.
This research highlights the importance of enolase 1-mediated production of phosphoenolpyruvate in tumor metabolism.

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Implication

Observational analysis reveals that the splicing inhibitor H3B-8800 modulates glycolysis and TCA cycle in tumors, implying new therapeutic strategies.

Abstract

The splicing inhibitor H3B-8800 modulates tumor glycolysis and TCA cycle

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Chen et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcb63 https://doi.org/10.1158/0008-5472.30363414

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Figure S1 from Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Figure S1 from Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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