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October 15, 2025Open Access

Figure S3 from Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production

Zeyu Chen Jingyu Liao Chang Zhu Ruizhi Chang Huifang Liang Zeyang Ding Zhao Huang Xiaoping Chen Jia Liang Bixiang Zhang

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Key Points

Exon skipping of SLK enhances glycolysis and leads to tumor progression.
This process results in increased phosphoenolpyruvate accumulation, indicating a metabolic shift.
The study indicates that higher SLK skipping correlates with a poorer prognosis in cancers.
These findings may have implications for targeting glycolytic pathways in cancer therapy.

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Implication

Exon skipping of SLK increases phosphoenolpyruvate in tumors, suggesting a link to poor patient outcomes.

Abstract

Exon skipping of SLK promotes PEP accumulation and predicts poor prognosis

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dcea4 https://doi.org/10.1158/0008-5472.30363405

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S7 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
2Figure S2 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
3Figure S8 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
4Figure S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
5Figure S6 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025

Figure S1 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
Table S5 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025
Table S4 from Exon Skipping of <i>Ste20-</i><i>Like</i><i> Kinase</i> Enhances Glycolysis and Tumor Progression by Activating Enolase 1–Mediated Phosphoenolpyruvate Production2025