Analysis shows POU2F1 reporter activity varies by rs9461276 allelic status in cancer cells, suggesting potential genetic implications.
Figure S9. tRF-18-HSQS52D2-mediated regulation of POU2F1 3'UTR reporter activity depends on rs9461276 allelic status. The relative reporter gene activity of vectors containing either the wild-type POU2F1 mRNA 3'UTR sequence (POU2F1-3'UTR-WT) or the mutant POU2F1 mRNA 3'UTR sequence (POU2F1-3'UTR-Mut) in HCT116 (A) and SW480 (B) cells. These cells were transfected with vectors containing the rs9461276-T allele, the rs9461276-C allele, an empty vector (pLKO.1), or were left non-transfected (Vehicle). Data are shown as the mean ± SD and all P-values were calculated using a two-sided Student’s t-test. ns, not significant.
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