Functional analysis reveals that rs9461276 modulates tRNA-derived fragments and impacts POU2F1 expression.
Figure S7. Functional characterization of the regulatory role of rs9461276 in modulating tRF-18-HSQS52D2 expression and their interaction with POU2F1. A, tRF-18-HSQS52D2 overexpression plasmids containing rs9461276-T or C alleles in HCT116 and SW480 cells. B, Sequences of tRF-18-HSQS52D2 and its potential binding site at the 3′UTR of POU2F1 mRNA, which is predicted by tRFTar database. C, Luciferase reporter vector containing the POU2F1-3′UTR-WT and POU2F1-3′UTR-Mut.
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Li et al. (2025) studied this question.
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