Observational analysis shows tRNA-derived fragments influence proliferation rates in colon cancer cells, highlighting their potential role in cancer risk.
Figure S10. The effect of tRF-18-HSQS52D2 and POU2F1 overexpression on the proliferation rates in HCT116 (left) and SW480 (right) cells. These cells were transfected with tRF-18-HSQS52D2-mimics, POU2F1 overexpression plasmids, NC-mimics or were left non-transfected (Vehicle). Data are shown as the mean ± SEM from three experiments, each with three replicates. **P < 0.01 and ****P < 0.0001 are derived from comparison with controls by a two-sided Student's t-test in 96 h. ns, not significant.
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Li et al. (2025) studied this question.
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