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October 22, 2025The European Research JournalOpen Access

Intracellular angiotensin-II measurement in streptozotocin-induced rat vascular smooth muscle cells and its relationship with angiotensin-II receptors

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Authors

ZÇZehra ÇiçekKAKübra AkıllıoğluZYZehra Gül Yaşar

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Overview

Analysis reveals Ang-II influences proliferation in vascular smooth muscle cells from diabetic rats, suggesting implications for treatment.

Key Points

  • Angiotensin-II enhances proliferation of vascular smooth muscle cells in diabetes and healthy conditions.
  • Increased vascular smooth muscle cell growth occurred in 0.1 and 0.01 μM Ang-II among diabetic rats.
  • Cell proliferation was evaluated by MTT assay, using antagonists for Ang-II type 1 and 2 receptors.
  • Olmesartan inhibited proliferation in healthy vascular smooth muscle cells, indicating receptor involvement.

Cite This Study

Çiçek et al. (2025) studied this question.

synapsesocial.com/papers/68f8a381c0c01e5ef8abdd75https://doi.org/10.18621/eurj.1760073
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Angiotensin II on the Growth of Vascular Smooth Muscle Cells1999 · 1 citations
  2. 2Receptor-mediated effects of angiotensin II on growth of vascular smooth muscle cells from spontaneously hypertensive rats.1992 · 131 citations
  3. 3Angiotensin III activates ERK1/2 mitogen activated protein kinases and proliferation of rat vascular smooth muscle cells2025 · 2 citations
  4. 4Intracellular Angiotensin II and cell growth of vascular smooth muscle cells2001 · 41 citations
  5. 5ANGIOTENSIN II‐INDUCED GROWTH OF VASCULAR SMOOTH MUSCLE CELLS IS ASSOCIATED WITH MODULATION OF CELL SURFACE AREA AND PLATELET‐DERIVED GROWTH FACTOR RECEPTOR EXPRESSION2007 · 7 citations