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October 23, 2025Journal of Pharmaceutical Health Care and SciencesOpen Access

Natural relief for premenstrual syndrome (PMS): a double-blind clinical trial on the efficacy and safety of PMSoff

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Authors

FSFatemeh SaghafiPZParisa ZareNHNooshin Hatamizadeh

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Overview

Randomized trial demonstrated PMSoff improved premenstrual syndrome symptoms in women, indicating potential as an alternative treatment.

Key Points

  • PMSoff significantly reduced PMS symptoms after two months of treatment, as measured by the Daily Record of Severity of Problems (DRSP).
  • Of the 218 women enrolled, adherence to medication was reported at 72% during the initial treatment months.
  • This randomized double-blind clinical trial evaluated the natural supplement PMSoff against a placebo on symptom severity and safety.
  • Findings support PMSoff's potential as a natural alternative or adjunct to standard pharmacological treatments for PMS and PMDD.

Cite This Study

Saghafi et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f74213dhttps://doi.org/10.1186/s40780-025-00495-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effects of FemmeBalance Supplement on Symptoms of Premenstrual Syndrome: A Four-Cycle Single-Arm Observational Study of a Novel Nutritional Supplement2025
  2. 2Empowering Women Through Pharmaceutical Education: A New Approach to Premenstrual Syndrome2026
  3. 3Dietary Approach to Premenstrual Syndrome Symptoms Alleviation – A Systematic Review2025
  4. 4Comparative efficacy and safety of oral pharmacological and complementary interventions for premenstrual syndrome: a protocol for a systematic review and a network meta-analysis2026
  5. 5Premenstrual Syndrome: Exploring the Role of Current Understanding of Lifestyle Factors and Future Research Prospects2026