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This study aims to evaluate the diagnostic power of plasma levels of CHI3L1 and other biomarkers in neurodegenerative diseases.

Plasma Levels of Chitinase 3‐Like 1 Protein Increase in Patients With Neurodegenerative Diseases: A Small Cohort Study

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This study aims to evaluate the diagnostic power of plasma levels of CHI3L1 and other biomarkers in neurodegenerative diseases.
Measured plasma levels of CHI3L1 and other markers in healthy controls and patients with Alzheimer's disease and Parkinson's disease
Utilized ELISA for quantification of biomarkers
Analyzed correlations and diagnostic sensitivity using ROC curves
CHI3L1 levels were significantly elevated in Alzheimer's and Parkinson's patients compared to controls
IL‐6 level increases correlated positively with CHI3L1 in Alzheimer's patients and negatively in Parkinson's patients
CHI3L1 demonstrated better sensitivity and specificity as a diagnostic biomarker over other markers

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Small cohort study shows elevated biomarkers in Alzheimer's and Parkinson's patients, indicating potential disease pathways.

Aldogan et al. (2025) studied this question.

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