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This research aims to assess how preanalytical factors influence CHI3L1 levels in blood and their relationship to levels in cerebrospinal fluid.

Impact of preanalytical factors on blood CHI3L1 levels

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This research aims to assess how preanalytical factors influence CHI3L1 levels in blood and their relationship to levels in cerebrospinal fluid.
Used Single Molecule Array (Simoa) assay for measuring CHI3L1 levels in serum, plasma, and CSF.
Conducted flow cytometry to identify CHI3L1 production sources in PBMCs.
Investigated the effects of delayed processing and freeze-thaw cycles on serum CHI3L1 levels.
Found a strong correlation between serum, plasma, and CSF CHI3L1 levels.
Serum CHI3L1 levels remained stable with delayed processing for up to 6 hours.
Classical monocytes were identified as the main producers of CHI3L1 in PBMCs.

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The study evaluates how blood processing affects CHI3L1 levels in MS, indicating standardized guidelines for its use as a biomarker.

Comabella et al. (2026) studied this question.

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