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The research aims to explore CHI3L1 expression in neutrophils and plasma from MS patients to assess its potential as a biomarker.

CHI3L1 Expression in Neutrophils and Plasma of Multiple Sclerosis Patients: Implications for Pathogenesis and a Potential Biomarker

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The research aims to explore CHI3L1 expression in neutrophils and plasma from MS patients to assess its potential as a biomarker.
Assessed intracellular CHI3L1 expression in CD66b+ neutrophils and CD16+ cells using flow cytometry.
Analyzed subcellular localization of CHI3L1 with confocal microscopy using neutrophil granule markers.
Measured plasma CHI3L1 and lactoferrin levels through ELISA.
Intracellular CHI3L1 levels and the proportion of CD66b+ cells significantly increased in MS patients.
CHI3L1 colocalized with CD66b+ specific granules.
Significant increases in intracellular and plasma CHI3L1 were found in DMF-treated MS patients compared to untreated patients.

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Study investigates CHI3L1 levels in neutrophils and plasma of MS patients, suggesting its role as a biomarker.

Jatczak‐Pawlik et al. (2026) studied this question.

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